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KMID : 0438219720090020173
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Korea University Medical Journal
1972 Volume.9 No. 2 p.173 ~ p.182
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A Study on Histological Changes in the Gonads, and Changes in Content of Water and Electrolytes in the Tissue of the Uterus and Stomach of Immture Rabbits by Reserpine Administration
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Abstract
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Reserpine has been used as hypotensive and diuretic not only for toxemia of pregnancy but also for some other conditions in the gynecological field. Althongh reserpine decreases blood pressure, it has a number of untoward side effects such as inhabition of gonadal stimulation, induction of Gastric ulcer, i etc.
The another has studied the responses of reserpine to the gonads and changes in content of water and electrolytes in the uterus and stomach of Immature female raffits, weighing around 1.5kg, A Group of rabbits conditioned with 50 I. U. /Kg of H. C. G. and another group with 1.5mg/Kg of reserpine plus 50 I. U. /Kg of H. C. G. were observed 24 hours after conditioning.
The results obtained were as followes:
1. The H. C. G. conditioned rabbits showed remarkable acceleration in maturation of the follicles and ovulation in the ovaries while the reserpine plus H.C.G. conditioned group showed an obvions suppression in ovulation.
2. Water and chloride in the uterine tissue of the H.C.G. conditioned rabbits showed increase in content compared to the control group. On the contrary. sodium. potassium, and magnesium were decreased in each in level. All the above mentioned electrolytes in the reserpine plus H. C. G. conditioned rabbits were reduced in each level.
3 Water and chloride in the stomach tissue were inereased in level, Whereas sodium, calcium, and magnesium decreased in H. C. G. conditioned rabbits. In the reserpine plus H. C. G. conditioned group, water chloride, calcium, Plus H. C. G. conditioned group, water, chloride, calcium, and magnesium were decreased in each level, but only the sodium level increased.
4. The content of water in the uterine tissiue of the H. C. G. conditioned group and that of reserpine plus H.C.G. conditioned one were less than that in the stomach tissue but, chloride and sodium in the uterine tissue showed higher levels than in the stomach tissue, especially, potassium, calcium, and magnesium levels showed nearly twice as much as in the stomach tissue.
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